Special For The HBN Radio Audience


Bill Sardi, Knowledge of Health

First, I am going to instruct you what to do.

Then I am going to tell you why.

Here is what I want you to write down or print out.  This is a daily regimen for adults:

  • Vitamin D3: if you haven’t been taking vitamin D daily,
    then take 50,000 units of vitamin D for five days to refill your liver stores; then take 8000 units of vitamin D3 daily (a published report entitled The Big Vitamin D Mistake reveals public health officials made a mathematical error and miscalculated how much vitamin D3 adults should be getting — 8000 units daily; 2000 units/day for children.
  • Zinc: 15-30 milligrams
  • Selenium: 200 micrograms to release zinc
  • Polyphenols: resveratrol, quercetin, fisetin, catechin (green tea), cinnamon totaling no more than 350 milligrams to sensitize your cells to vitamin D.
  • If you are chronically or acutely ill, then consider adding any of the following items to your daily regimen to fully activate your immune system:
    • Fucoidan seaweed extract: 300-600 milligrams
    • Forskolin from coleus: 100-300 mg
    • IP6 rice bran extract 400-800 mg

Some of above nutrients may already be provided in your daily multivitamin or other supplements you take.

Now, here is why:

In many people, their body never converts vitamin D to its active form, CALCITRIOL. (Pronunciation: CAL-Si-Tree-oL).  In particular, diabetics and overweight individuals.  Therefore, blood tests that only measure the amount of sunshine vitamin D3 (cholecalciferol), not calcitriol, may be misleading!

Vitamin D science is mixed and doctors haven’t universally embraced vitamin D because there are confusing studies.  Even though millions of Americans have very low vitamin D blood levels, vitamin D supplementation hasn’t always resolved health problems associated with low vitamin D.  Now we know why.

Zinc is needed to help convert vitamin D3 to its intermediate form (called CALCIDIOL) in the liver, where vitamin D is stored for use in winter months, and then to CALCITRIOL, its active form that is metabolized in the kidneys. 

How to get vitamin D inside cells

The next lesson is there is a molecular doorway for vitamin D inside or on the surface of cells, called a cell receptor site.  The VITAMIN D RECEPTOR is wide open when polyphenols like resveratrol, fisetin, quercetin, are consumed.  This is called sensitizing the vitamin D receptor. Taking supplemental polyphenols helps vitamin D enter your cells.

Indeed, studies reveal mild plant estrogen-like molecules mentioned above can enzymatically activate vitamin D as calcitriol.  Estrogen-like molecules, such as resveratrol, quercetin, fisetin, catechin, have been commercialized and are widely available.

One of the major reasons why the red wine molecule resveratrol exerts such broad and almost magical biological and genetic activity is that it sensitizes the vitamin D cell receptor (VDR).  Vitamin D elevates intracellular levels of resveratrol.  Likewise, resveratrol potentiates vitamin D via the vitamin D receptor.  Similarly, quercetin, another natural polyphenolic molecule, interacts with the vitamin D receptor.  Researchers conclude: Quercetin-based vitamin D receptor (VDR) modulators could represent novel therapies for various VDR-related disorders.

Chart shows concentration of resveratrol alone and when combined with vitamin D in cells. 

White blood cells

Vitamin D is very important for maintenance of your immune system because it is needed to make white blood cells called neutrophils, the first army of white blood cells to arrive at sites of infection, burns, or wounds.  But vitamin D is also important to produce another important white blood cell, macrophages.

The trace mineral zinc facilitates maximum calcitriol levels via release from macrophages.  Zinc is commonly deficient among patients with kidney disease.

And an important fact for individuals who are currently battling cancer or attempting to prevent its recurrence.  Calcitriol suppresses the Warburg Effect, the well-known phenomenon whereby tumor cells revert to utilizing sugar rather than fat for energy.

Now for part 2

Vitamin D is transported from the liver to the kidneys via VITAMIN D BINDING PROTEIN.  Vitamin D binding protein can convert to MACROPHAGE ACTIVATING FACTOR.  Macrophages are another form of white blood cell that literally digests, engulfs and surrounds germs and tumor cells. 

Macrophages are the “janitors” of the human body.  Every day between 173-259 billion red blood cells are produced in the bone marrow and roughly the same number die off Macrophages, their discovery the subject of a Nobel Prize in 1903 by Elie Metchnikoff, clear the circulatory system of 2 X 1011 power or 2 X 100,000,000,000 or 200 billion dead red blood cells every day.  Remarkable!

Macrophages kill germs and tumor cells.  Macrophages go by other names in different parts of the body:  glia (brain); retinal pigment epithelium (retina); Kupfer cell (liver); osteoclast (within bone); Langerhans cells (epidermis of skin)

The dreaded enzyme: nagalase

However, tumor cells produce an enzyme called nagalase that degrades MACROPHAGE ACTIVATING FACTOR (MAF).  Nagalase is a primary reason why we can’t beat cancer or chronic infections. 

Due to nagalase, our macrophages are sluggish and must be woken up.  Often macrophages are simply idling like an automobile in neutral gear with the engine running. 

Drinking alcohol will increase nagalase.  Iron overload increases nagalase.  Viruses and tumor cells can produce nagalase till your macrophages have simply gone to sleep. 

Nagalase’s ability to degrade MAF is so critical that its inhibition has been called the key to curing cancer.”

Why we can’t conquer TB

Of particular interest is to learn the mycobacterium that causes TUBERCULOSIS is a parasite that mainly attacks macrophages.  It is no wonder TB is such a dastardly lung disease, it resides within the human immune system itself. Vitamin D as CALCITRIOL significantly enhances macrophage activity in cases of tuberculosis. 

Where are the macrophages?

The largest pool of un-activated macrophages reside in the ileum (lower small intestine) in what are called Peyer’s Patches to “sterilize” the digestive tract.  This is where the most sleepy macrophages reside that must be woken up to combat germs and malignancies.

Macrophage function is intimately coupled with vitamin D metabolism.  Vitamin D inhibits inflammation caused by overactive macrophages to the point of normalcy.  On the other hand, macrophages control the availability of vitamin D via the vitamin D binding protein The status of vitamin D contributes to the germ-fighting capabilities of macrophages. 

Other companion dietary supplements

The seaweed cure

Of great interest is a report showing the algal seaweed extract fucoidan reduces the production of nagalase from cancerous cells

Fucoidan was put to the test head-to-head with calcitriol, the active form of vitamin D Fucoidan and calcitriol, both in cultured lab-dish cells and laboratory animals, improved kidney function. 

In the clinic, fucoidan is used at a 600-milligram dose/day (60-kilogram/ 132-lb) in humans.  In some aspects, fucoidan improved kidney function better than calcitriol.

Coleus forskolin

Coleus is a botanical supplement that has many applications via its active ingredient, forskolin.

A parathyroid gland hormone, cyclic AMP, increases calcidiol, an intermediate form of vitamin D.  Forskolin, derived from the botanical Coleus Forskohlii, increases calcidiol.

Forskolin has been shown to kill multiple myeloma cells in lab dishes via its ability to elevate cyclic AMP enzyme levels.

Cyclic AMP increases activity of the CYP27B1 gene that produces the liver enzyme involved in the biosynthesis of vitamin D.

Other studies show forskolin increases calcitriol production in kidney cells. In one published lab dish study forskolin increased vitamin D3 production 50-100%.

IP6 rice bran extract

Iron overload is prevalent with advancing age, particularly in men and alcohol imbibers.  In the blood disorder beta thalassemia where iron overload defines the disease, low vitamin D levels are prevalent.

Men with iron overload (hemochromatosis) and low vitamin D levels (calcidiol, the intermediate form of vitamin D) were corrected by blood-letting and concomitant reduction in iron stores.

Iron chelators such as rice bran IP6 may be appropriate in instances of iron overload to normalize vitamin D levels. IP6 (aka phytic acid or phytate) binds to phosphate and calcium and therefore inhibits over-calcification sometimes induced by calcitriol.

This is more than anyone wanted to know about vitamin D and the immune system.  The list of dietary supplements grows as we understand how to activate vitamin D to CALCITRIOL and to activate MACROPHAGES do to their job of housecleaning and elimination of pathogens. 

To keep the list of supplements short, focus on supplementing with vitamin D and zinc.  If you feel you need to make sure your body is making CALCITRIOL and ACTIVATING MACROPHAGES, you can add the additional nutrients, though this gets a bit complicated and costly.

Lifespan Nutrition has assembled all these nutrients, vitamin D, zinc, selenium, and if needed, IP6 rice bran, fucoidan from seaweed and forskolin from coleus, so you don’t have to shop everywhere to find these items.  Lifespan Nutrition can be reached at 800 247-5731. Or you can shop for them on your own.

In states of disease or infection macrophages are predominantly activated by vitamin D-binding protein/macrophage activating factor (MAF). 

Some people, especially those who are chronically or acutely ill, cannot activate their macrophages. 


Whereas MACROPHAGE ACTIVATING FACTOR stimulates MACROPHAGES, CALCITRIOL, the active form of vitamin D, keeps a lid on macrophage activation.  This is a balancing act.

Part 3

For people who can’t activate their macrophages naturally, I’m here to announce on Healthy By Nature radio that  MACROPHAGE ACTIVATING FACTOR is now commercially available as a dietary supplement.  It is the sure and direct way to activate your macrophages.  It is produced from milk protein by Saisei Pharm in Japan, who has just now introduced their advanced 3rd generation triple-strength MAF capsules. 

Because of its cost, $216 a bottle of 60 capsules, it is recommended to regain health, not maintain daily health. 


The phone number where you can get a supply of MAF is
702 682-9945 toll-free, and this number will also be posted at HBN.  MAF can be taken with medications and has no known side effects, since it is made naturally in a healthy human body. 

Of considerable interest is the revelation that the MAF dietary supplement produced by SAISEI PHARM appears to be resistant to nagalase degradation.

Beginning in 2008 I have both personally observed and read and reported on the near-miraculous remissions from the most dreaded conditions associated with reactivation of macrophages.  We can make no claim macrophage activation cures, prevents or treats any disease, it is important to optimize your immune system.  We can say a weak immune system is at the root of poor health. 


Vitamin D deficiency is estimated to occur among 87% of Covid-19 deaths.  It can’t be said vitamin D cures Covid-19, but it can be said infected patients should not be vitamin D deficient.

The failure to metabolize vitamin D to its active form CALCITRIOL and to address its concomitant choke-points, the VITAMIN D RECEPTOR and VITAMIN D BINDING PROTEIN to produce MACROPHAGE ACTIVATING FACTOR, to activate germ-killing macrophages, is a shameful blind-spot in modern medicine. 

MACROPHAGES are quiescent or idling, waiting to be woken up and activated in states of infection or malignancy. 

Modern medicine has its own forms of immunotherapy, and they cost hundreds of thousands of dollars.  The regimen described herein gives sick patients a chance to affordably optimize their immune system.

Viruses and tumor cells rampantly divide and overwhelm tissues and organs because they degrade MACROPHAGE ACTIVATING FACTOR via the enzyme NAGALASE.  At this desperate point, MACROPHAGE ACTIVATING FACTOR (MAF) itself must be administered.